CYP2D6 inhibitor
- Inhibits CYP2D6
- CYP2D6 substrate exposure can rise
- Effect is greatest for sensitive substrates
- Toxicity risk rises with narrow-index victims
- Inhibition often begins faster than induction
- Genotype and inhibitors can cause phenoconversion.
Interaction at a glance
Magnitude / time course
- Inhibits CYP2D6
- CYP2D6 substrate exposure can rise
- Effect is greatest for sensitive substrates
- Inhibition often begins faster than induction
Clinical consequence
- Toxicity risk rises with narrow-index victims
Mechanism
- Genotype and inhibitors can cause phenoconversion.
Self-check
- What is the main clinical risk of CYP2D6 inhibitor?
Toxicity risk rises with narrow-index victims.
- Which enzyme or transporter is central to the CYP2D6 inhibitor interaction?
CYP2D6.
Drugs in this interaction (14)
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