CYP2D6 inhibitor
- Inhibits CYP2D6
- CYP2D6 substrate exposure can rise
- Effect is greatest for sensitive substrates
- Toxicity risk rises with narrow-index victims
- Inhibition often begins faster than induction
- Genotype and inhibitors can cause phenoconversion.
Interaction at a glance
- Inhibits CYP2D6
Magnitude / time course
- Inhibits CYP2D6
- CYP2D6 substrate exposure can rise
- Effect is greatest for sensitive substrates
- Inhibition often begins faster than induction
Clinical consequence
- Toxicity risk rises with narrow-index victims
Mechanism
- Genotype and inhibitors can cause phenoconversion.
Self-check
- Key risk with CYP2D6 inhibitor?
Toxicity risk rises with narrow-index victims. - What can cause CYP2D6 phenoconversion?
Genotype and inhibitors.
Drugs in this interaction (14)
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