CYP2C9 phenotype-sensitive
- Clinical exposure depends strongly on CYP2C9 phenotype
- Genotype can shift efficacy and toxicity
- Strong inhibitors can mimic poor metabolism
- Prodrugs may show the opposite efficacy pattern
- Reduced function often slows clearance.
Interaction at a glance
- Clinical exposure depends strongly on CYP2C9 phenotype
Mechanism
- Strong inhibitors can mimic poor metabolism
Magnitude / time course
- Clinical exposure depends strongly on CYP2C9 phenotype
Clinical consequence
- Genotype can shift efficacy and toxicity
- Prodrugs may show the opposite efficacy pattern
Management
- Reduced function often slows clearance.
Self-check
- Key risk with CYP2C9 phenotype-sensitive?
Genotype can shift efficacy and toxicity. - How does reduced CYP2C9 function often affect clearance?
Slows it.
Drugs in this interaction (6)
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