CYP2B6 substrate
- Cleared substantially by CYP2B6
- CYP2B6 inhibitors can raise exposure
- CYP2B6 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Important for bupropion/efavirenz/methadone.
Interaction at a glance
- Cleared substantially by CYP2B6
Mechanism
- Cleared substantially by CYP2B6
Magnitude / time course
- CYP2B6 inhibitors can raise exposure
- CYP2B6 inducers can lower exposure
Mechanism / modifiers
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Important for bupropion/efavirenz/methadone.
Self-check
- Which pathway substantially clears drugs tagged as CYP2B6 substrate?
CYP2B6.
Drugs in this interaction (10)
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