CYP2B6 substrate
- Cleared substantially by CYP2B6
- CYP2B6 inhibitors can raise exposure
- CYP2B6 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Important for bupropion/efavirenz/methadone.
Interaction at a glance
- Cleared substantially by CYP2B6
Mechanism
- Cleared substantially by CYP2B6
Magnitude / time course
- CYP2B6 inhibitors can raise exposure
- CYP2B6 inducers can lower exposure
Mechanism / modifiers
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Important for bupropion/efavirenz/methadone.
Self-check
- What can happen to CYP2B6-substrate exposure when CYP2B6 is inhibited?
Exposure can rise. - What determines the clinical impact of a CYP2B6-substrate interaction?
Fraction metabolized.
Drugs in this interaction (10)
All interaction examples · Open CYP2B6 substrate in the interactive console ↗