CYP2B6 inducer
- Induces CYP2B6 activity/expression
- CYP2B6 substrates usually clear faster
- AUC/effect may fall → treatment failure
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Important for bupropion/efavirenz/methadone.
Interaction at a glance
- Induces CYP2B6 activity/expression
Mechanism
- Induces CYP2B6 activity/expression
- CYP2B6 substrates usually clear faster
Mechanism / modifiers
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Important for bupropion/efavirenz/methadone.
Clinical consequence
- AUC/effect may fall → treatment failure
Self-check
- How does CYP2B6 induction affect sensitive-substrate exposure?
It may fall. - How long do CYP2B6-induction onset and offset usually take?
Days.
Drugs in this interaction (7)
All interaction examples · Open CYP2B6 inducer in the interactive console ↗