CYP2B6 inducer
- Induces CYP2B6 activity/expression
- CYP2B6 substrates usually clear faster
- AUC/effect may fall → treatment failure
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Important for bupropion/efavirenz/methadone.
Interaction at a glance
- Induces CYP2B6 activity/expression
Mechanism
- Induces CYP2B6 activity/expression
- CYP2B6 substrates usually clear faster
Mechanism / modifiers
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Important for bupropion/efavirenz/methadone.
Clinical consequence
- AUC/effect may fall → treatment failure
Self-check
- What usually happens to a sensitive CYP2B6 substrate when a CYP2B6 inducer is added?
Its exposure decreases.
Drugs in this interaction (7)
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