CYP1A2 substrate
- Cleared substantially by CYP1A2
- CYP1A2 inhibitors can raise exposure
- CYP1A2 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Smoking is a major environmental modifier.
Interaction at a glance
- Cleared substantially by CYP1A2
Magnitude / time course
- Cleared substantially by CYP1A2
- CYP1A2 inhibitors can raise exposure
Exposure modifiers
- CYP1A2 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
Mechanism
- Smoking is a major environmental modifier.
Self-check
- What can happen to CYP1A2-substrate exposure when CYP1A2 is inhibited?
Exposure can rise. - What determines the clinical impact of a CYP1A2-substrate interaction?
Fraction metabolized.
Drugs in this interaction (23)
All interaction examples · Open CYP1A2 substrate in the interactive console ↗