CYP1A2 substrate
- Cleared substantially by CYP1A2
- CYP1A2 inhibitors can raise exposure
- CYP1A2 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Smoking is a major environmental modifier.
Interaction at a glance
- Cleared substantially by CYP1A2
Magnitude / time course
- Cleared substantially by CYP1A2
- CYP1A2 inhibitors can raise exposure
Exposure modifiers
- CYP1A2 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
Mechanism
- Smoking is a major environmental modifier.
Self-check
- Which pathway substantially clears drugs tagged as CYP1A2 substrate?
CYP1A2.
Drugs in this interaction (23)
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