CYP1A2 inducer
- Induces CYP1A2 activity/expression
- CYP1A2 substrates usually clear faster
- AUC/effect may fall → treatment failure
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Smoking is a major environmental modifier.
Interaction at a glance
- Induces CYP1A2 activity/expression
Mechanism
- Induces CYP1A2 activity/expression
- CYP1A2 substrates usually clear faster
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
Clinical consequence
- AUC/effect may fall → treatment failure
Mechanism / modifiers
- Smoking is a major environmental modifier.
Self-check
- How long does CYP1A2 induction onset/offset usually take?
Over days. - How does CYP1A2 induction affect sensitive-substrate exposure?
It may fall.
Drugs in this interaction (7)
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