CYP1A2 inducer
- Induces CYP1A2 activity/expression
- CYP1A2 substrates usually clear faster
- AUC/effect may fall → treatment failure
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Smoking is a major environmental modifier.
Interaction at a glance
- Induces CYP1A2 activity/expression
Mechanism
- Induces CYP1A2 activity/expression
- CYP1A2 substrates usually clear faster
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
Clinical consequence
- AUC/effect may fall → treatment failure
Mechanism / modifiers
- Smoking is a major environmental modifier.
Self-check
- Which enzyme or transporter is central to the CYP1A2 inducer interaction?
CYP1A2.
- What usually happens to a sensitive CYP1A2 substrate when a CYP1A2 inducer is added?
Its exposure decreases.
Drugs in this interaction (7)
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