COMT substrate
- Metabolized by catechol-O-methyltransferase
- Applies mainly to catechol-containing compounds
- COMT inhibition can prolong catechol exposure
- Levodopa pathway is the classic clinical context
- Other clearance routes often contribute
Interaction at a glance
- Metabolized by catechol-O-methyltransferase
Mechanism
- Metabolized by catechol-O-methyltransferase
- Applies mainly to catechol-containing compounds
Magnitude / time course
- Levodopa pathway is the classic clinical context
- Other clearance routes often contribute
Exposure modifiers
- COMT inhibition can prolong catechol exposure
Self-check
- Which pathway metabolizes a COMT substrate?
catechol-O-methyltransferase.
Drugs in this interaction (7)
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