Absorption (bile-acid sequestrant interaction)
- Sequestrant binds drugs within the intestine
- Oral bioavailability can fall substantially
- Cholestyramine is especially interaction-prone
- Give vulnerable drugs well before/after resin
- Also lowers absorption of fat-soluble vitamins
Interaction at a glance
- Sequestrant binds drugs within the intestine
Mechanism
- Sequestrant binds drugs within the intestine
- Oral bioavailability can fall substantially
Mechanism / modifiers
- Cholestyramine is especially interaction-prone
- Give vulnerable drugs well before/after resin
Mechanism / exceptions
- Also lowers absorption of fat-soluble vitamins
Self-check
- What does a bile-acid sequestrant do to interacting oral drugs?
Binds them in the intestine and can reduce absorption.
Drugs in this interaction (11)
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