GABA-A neuroactive steroids
- Positive allosteric GABA-A modulators
- Steroid-derived binding sites differ from BZDs
- Brexanolone/zuranolone treat postpartum depression
- Sedation/somnolence are prominent
- Rapid-onset antidepressant effects are distinctive
- Driving/CNS-depressant precautions matter
Class at a glance
- Positive allosteric GABA-A modulators
Practical pearls
- Steroid-derived binding sites differ from BZDs
Clinical role
- Brexanolone/zuranolone treat postpartum depression
- Rapid-onset antidepressant effects are distinctive
- Driving/CNS-depressant precautions matter
Safety / monitoring
- Sedation/somnolence are prominent
Drugs in this class (7)
All drug classes · Open the interactive console ↗
