Antihyperglycemics (sulfonylureas)
- Stimulate insulin release regardless glucose
- Cheap + effective A1c lowering
- Main cost: hypoglycemia + weight gain
- Glipizide often favored in CKD
- Glyburide → more/prolonged hypoglycemia
- No cardiorenal outcome advantage
- Often displaced by safer modern drugs
Class at a glance
- Stimulate insulin release regardless glucose
Practical pearls
- Often displaced by safer modern drugs
Clinical role
- Cheap + effective A1c lowering
- Glipizide often favored in CKD
- Glyburide → more/prolonged hypoglycemia
Members / distinctions
- Main cost: hypoglycemia + weight gain
- No cardiorenal outcome advantage
Self-check
- What do Antihyperglycemics (sulfonylureas) stimulate?
insulin release regardless glucose.
Drugs in this class (4)
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