Antiarrhythmics (Vaughan-Williams IA)
- Moderate Na+ block + K+ channel block
- Slow conduction and prolong repolarization
- Quinidine/procainamide/disopyramide
- QRS and QT can both widen
- Torsades + proarrhythmia are major limits
- Mostly niche/specialist drugs now
Class at a glance
- Moderate Na+ block + K+ channel block
Members / distinctions
- Slow conduction and prolong repolarization
- Quinidine/procainamide/disopyramide
Safety / monitoring
- QRS and QT can both widen
Other member distinctions
- Torsades + proarrhythmia are major limits
- Mostly niche/specialist drugs now
Self-check
- What is the main pharmacologic action of Antiarrhythmics (Vaughan-Williams IA)?
Moderate Na+ block + K+ channel block.
Drugs in this class (6)
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