Pain (neuropathic)
- Treat cause + function, not pain score alone
- First-line: gabapentinoid or SNRI
- gabapentin/pregabalin; duloxetine
- TCA effective if antimuscarinic risk acceptable
- Topical therapy for focal neuropathic pain
- Opioids generally later-line/rescue
- Reassess benefit vs sedation/weight/falls
Use at a glance
- Treat cause + function, not pain score alone
Escalation / refractory disease
- First-line: gabapentinoid or SNRI
- gabapentin/pregabalin; duloxetine
- Opioids generally later-line/rescue
Treatment options
- Topical therapy for focal neuropathic pain
Monitoring / follow-up
- TCA effective if antimuscarinic risk acceptable
- Reassess benefit vs sedation/weight/falls
Self-check
- What safety issue limits TCAs for neuropathic pain?
Antimuscarinic risk. - What is first-line for neuropathic pain?
Gabapentinoid or SNRI.
Drugs used for this (14)
All clinical uses · Open Pain (neuropathic) in the interactive console ↗