Depressive disorders

Psychotherapy and antidepressants are core options
SSRIs/SNRIs commonly start pharmacotherapy
Bupropion or mirtazapine also first-line options
Severe/psychotic depression may need ECT or combination
Treatment-resistant illness → augmentation/switch/ECT
Continue after remission to reduce relapse

Use at a glance

Psychotherapy and antidepressants are core options

Treatment options

SSRIs/SNRIs commonly start pharmacotherapy
Choose by prior response, symptoms + adverse effects

Other treatment options

Treatment-resistant illness → augmentation/switch/ECT
Continue after remission to reduce relapse

Practical pearls

Severe/psychotic depression may need ECT

Self-check

What factors should guide treatment choice for Depressive disorders?
prior response, symptoms + adverse effects.
What is recommended for Treatment-resistant illness in Depressive disorders?
Electroconvulsive therapy

Drugs used for this (39)

Trazodone ballicule — decagon mechanism diagram — Trazodone — off-label

Sertraline ballicule — decagon mechanism diagram — Sertraline — off-label

Duloxetine ballicule — decagon mechanism diagram — Duloxetine — off-label

Escitalopram ballicule — decagon mechanism diagram — Escitalopram — off-label

Quetiapine ballicule — decagon mechanism diagram — Quetiapine — off-label

Bupropion ballicule — decagon mechanism diagram — Bupropion — off-label

Mirtazapine ballicule — decagon mechanism diagram — Mirtazapine — off-label

Fluoxetine ballicule — decagon mechanism diagram — Fluoxetine — off-label

Citalopram ballicule — decagon mechanism diagram — Citalopram — off-label

Venlafaxine ballicule — decagon mechanism diagram — Venlafaxine — off-label

Aripiprazole ballicule — decagon mechanism diagram — Aripiprazole — off-label

Amitriptyline ballicule — decagon mechanism diagram — Amitriptyline — off-label

Paroxetine ballicule — decagon mechanism diagram — Paroxetine — off-label

Nortriptyline ballicule — decagon mechanism diagram — Nortriptyline — off-label

Doxepin ballicule — decagon mechanism diagram — Doxepin — off-label

Desvenlafaxine ballicule — decagon mechanism diagram — Desvenlafaxine — off-label

Cariprazine ballicule — decagon mechanism diagram — Cariprazine — off-label

Vortioxetine ballicule — decagon mechanism diagram — Vortioxetine — off-label

Brexpiprazole ballicule — decagon mechanism diagram — Brexpiprazole — off-label

Vilazodone ballicule — decagon mechanism diagram — Vilazodone — off-label

Imipramine ballicule — decagon mechanism diagram — Imipramine — off-label

Desipramine ballicule — decagon mechanism diagram — Desipramine — off-label

Levomilnacipran ballicule — decagon mechanism diagram — Levomilnacipran — off-label

Phenelzine ballicule — decagon mechanism diagram — Phenelzine — off-label

Tranylcypromine ballicule — decagon mechanism diagram — Tranylcypromine — off-label

Protriptyline ballicule — decagon mechanism diagram — Protriptyline — off-label

Nefazodone ballicule — decagon mechanism diagram — Nefazodone — off-label

Amoxapine ballicule — decagon mechanism diagram — Amoxapine — off-label

Trimipramine ballicule — decagon mechanism diagram — Trimipramine — off-label

Isocarboxazid ballicule — decagon mechanism diagram — Isocarboxazid — off-label

Gepirone ballicule — decagon mechanism diagram — Gepirone — off-label

Maprotiline ballicule — decagon mechanism diagram — Maprotiline — off-label

Buspirone ballicule — decagon mechanism diagram — Buspirone — off-label

Lithium ballicule — decagon mechanism diagram — Lithium — off-label

Fluvoxamine ballicule — decagon mechanism diagram — Fluvoxamine — off-label

Brexanolone ballicule — decagon mechanism diagram — Brexanolone — off-label

Zuranolone ballicule — decagon mechanism diagram — Zuranolone — off-label

Esketamine ballicule — decagon mechanism diagram — Esketamine — off-label

Ketamine ballicule — decagon mechanism diagram — Ketamine — off-label

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