Bipolar disorder

Acute mania: lithium/valproate or antipsychotic
Severe mania often needs combination therapy
Bipolar depression: agent-specific evidence matters

lithium, lamotrigine + selected SGAs

Maintenance should match prior episode polarity
Antidepressants not helpful, may destabilize

Use at a glance

Acute mania: lithium/valproate or antipsychotic

Practical pearls

Maintenance should match prior episode polarity

Choosing treatment

Severe mania often needs combination therapy
Bipolar depression: agent-specific evidence matters

lithium, lamotrigine + selected SGAs

Safety / pitfalls

Antidepressants rarely helpful and may destabilize

Self-check

What is needed for Severe mania in Bipolar disorder?
combination therapy.
What should generally be avoided in Bipolar disorder?
antidepressants

Drugs used for this (15)

Quetiapine ballicule — decagon mechanism diagram — Quetiapine — off-label

Valproate ballicule — decagon mechanism diagram — Valproate — off-label

Aripiprazole ballicule — decagon mechanism diagram — Aripiprazole — off-label

Risperidone ballicule — decagon mechanism diagram — Risperidone — off-label

Carbamazepine ballicule — decagon mechanism diagram — Carbamazepine — off-label

Lithium ballicule — decagon mechanism diagram — Lithium — off-label

Ziprasidone ballicule — decagon mechanism diagram — Ziprasidone — off-label

Cariprazine ballicule — decagon mechanism diagram — Cariprazine — off-label

Asenapine ballicule — decagon mechanism diagram — Asenapine — off-label

Iloperidone ballicule — decagon mechanism diagram — Iloperidone — off-label

Milsaperidone ballicule — decagon mechanism diagram — Milsaperidone — off-label

Lurasidone ballicule — decagon mechanism diagram — Lurasidone — off-label

Lumateperone ballicule — decagon mechanism diagram — Lumateperone — off-label

Lamotrigine ballicule — decagon mechanism diagram — Lamotrigine — off-label

Olanzapine ballicule — decagon mechanism diagram — Olanzapine

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