Precursor to metabolite: Divalproex DR to 4-ene-VPA
Divalproex DR is converted to 4-ene-VPA by CYP2C9.
The pair
- Divalproex DR — Delayed-release broad-spectrum antiseizure drug and mood stabilizer; highly teratogenic.
- 4-ene-VPA — Unsaturated valproate metabolite implicated in mitochondrial dysfunction and liver toxicity; not a separate therapeutic drug.
Anything that inhibits or induces CYP2C9 shifts the balance between Divalproex DR and 4-ene-VPA.
Divalproex DR · 4-ene-VPA · Open Divalproex DR in the interactive console ↗