Precursor to metabolite: Quetiapine XR to Norquetiapine
Quetiapine XR is converted to Norquetiapine by CYP3A4.
The pair
- Quetiapine XR — Extended-release quetiapine for schizophrenia and adjunctive depression; highly sedating.
- Norquetiapine — Active quetiapine metabolite; supplies the norepinephrine reuptake block and muscarinic blockade the parent lacks.
Anything that inhibits or induces CYP3A4 shifts the balance between Quetiapine XR and Norquetiapine.
Quetiapine XR · Norquetiapine · Open Quetiapine XR in the interactive console ↗