Precursor to metabolite: Quetiapine XR to Norquetiapine
Quetiapine XR is converted to Norquetiapine by CYP3A4.
The pair
- Quetiapine XR — Extended-release quetiapine for schizophrenia and adjunctive depression; highly sedating.
- Norquetiapine — Quetiapine's active metabolite, and the source of the norepinephrine reuptake block and muscarinic blockade the parent lacks.
Anything that inhibits or induces CYP3A4 shifts the balance between Quetiapine XR and Norquetiapine.
Quetiapine XR · Norquetiapine · Open Quetiapine XR in the interactive console ↗