Precursor to metabolite: Quetiapine to Norquetiapine
Quetiapine is converted to Norquetiapine by CYP3A4.
The pair
- Quetiapine — Sedating atypical for schizophrenia and bipolar depression; metabolic burden at any dose.
- Norquetiapine — Active quetiapine metabolite; supplies the norepinephrine reuptake block and muscarinic blockade the parent lacks.
Anything that inhibits or induces CYP3A4 shifts the balance between Quetiapine and Norquetiapine.
Quetiapine · Norquetiapine · Open Quetiapine in the interactive console ↗