Precursor to metabolite: Primidone to Phenobarbital
Primidone is converted to Phenobarbital by CYP2C19.
The pair
- Primidone — Deoxybarbiturate for essential tremor and seizures; active itself, partly converted to phenobarbital.
- Phenobarbital — Oldest barbiturate anticonvulsant; sedating, enzyme-inducing, largely historical.
Anything that inhibits or induces CYP2C19 shifts the balance between Primidone and Phenobarbital.
Primidone · Phenobarbital · Open Primidone in the interactive console ↗