Precursor to metabolite: Nefazodone to Hydroxynefazodone
Nefazodone is converted to Hydroxynefazodone by CYP3A4.
The pair
- Nefazodone — SARI with rare fatal hepatotoxicity; brand withdrawn, generic still available.
- Hydroxynefazodone — Nefazodone metabolite that keeps the parent's 5-HT2A blockade.
Anything that inhibits or induces CYP3A4 shifts the balance between Nefazodone and Hydroxynefazodone.
Nefazodone · Hydroxynefazodone · Open Nefazodone in the interactive console ↗