Precursor to metabolite: Nefazodone to Hydroxy nefazodone
Nefazodone is converted to Hydroxy nefazodone by CYP3A4.
The pair
- Nefazodone — SARI withdrawn in some markets for hepatotoxicity; rarely prescribed today.
- Hydroxy nefazodone — Nefazodone metabolite that keeps the parent's 5-HT2A blockade.
Anything that inhibits or induces CYP3A4 shifts the balance between Nefazodone and Hydroxy nefazodone.
Nefazodone · Hydroxy nefazodone · Open Nefazodone in the interactive console ↗