Precursor to metabolite: Losartan to EXP3179
Losartan is converted to EXP3179 by CYP2C9.
The pair
- Losartan — The first ARB; also lowers uric acid.
- EXP3179 — Losartan's aldehyde intermediate; no AT1 activity, a PPAR-γ partial agonist / COX-2 inhibitor.
Anything that inhibits or induces CYP2C9 shifts the balance between Losartan and EXP3179.
Losartan · EXP3179 · Open Losartan in the interactive console ↗