Precursor to metabolite: Ifosfamide to Phosphoramide mustard
Ifosfamide is converted to Phosphoramide mustard by CYP3A4.
The pair
- Ifosfamide — Alkylating chemotherapy; neurotoxic, needs mesna for cystitis.
- Phosphoramide mustard — DNA-crosslinking metabolite responsible for much of cyclophosphamide's antitumor activity; also drives marrow and reproductive toxicity.
Anything that inhibits or induces CYP3A4 shifts the balance between Ifosfamide and Phosphoramide mustard.
Ifosfamide · Phosphoramide mustard · Open Ifosfamide in the interactive console ↗