Phosphoramide mustard
from cyclophosphamide
What it isThe DNA-crosslinking metabolite of cyclophosphamide and ifosfamide.
Why it mattersIt is the species that actually alkylates DNA — the parents are inert until CYP activates them.
What it changes⛑ Acrolein, the other product of that activation, causes the hemorrhagic cystitis. Mesna binds acrolein and does not touch this.
NO BOXED WARNINGS
Principal riskAcrolein from the same activation causes cystitis
Classes and tags
Clinical profile
Mechanism of action: Phosphoramide mustard ballicule
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