Precursor to metabolite: Ifosfamide to Chloroacetaldehyde
Ifosfamide is converted to Chloroacetaldehyde by CYP3A4.
The pair
- Ifosfamide — Alkylating chemotherapy; neurotoxic, needs mesna for cystitis.
- Chloroacetaldehyde — Toxic ifosfamide metabolite implicated in encephalopathy and kidney injury; distinct from bladder-toxic acrolein.
Anything that inhibits or induces CYP3A4 shifts the balance between Ifosfamide and Chloroacetaldehyde.
Ifosfamide · Chloroacetaldehyde · Open Ifosfamide in the interactive console ↗