Chloroacetaldehyde
from ifosfamide
What it isReactive metabolite of ifosfamide.
Why it mattersIt is the leading explanation for ifosfamide’s neurotoxicity (encephalopathy) and contributes to nephrotoxicity — toxicities cyclophosphamide largely lacks.
What it changesMethylene blue and supportive care address encephalopathy; this metabolite explains why ifosfamide, not cyclophosphamide, causes it.
NO BOXED WARNINGS
Classes and tags
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Self-check
- Which parent produces chloroacetaldehyde?
Ifosfamide. - What addresses the associated encephalopathy?
Methylene blue and supportive care.