Precursor to metabolite: Desmethyl cariprazine to Didesmethyl cariprazine

Desmethyl cariprazine is converted to Didesmethyl cariprazine by CYP3A4.

The pair

Desmethyl cariprazine — Cariprazine metabolite with the same D3-preferring partial agonism as the parent.
Didesmethyl cariprazine — Cariprazine's long-lived second metabolite — the reason steady state takes weeks and washout takes longer.

Anything that inhibits or induces CYP3A4 shifts the balance between Desmethyl cariprazine and Didesmethyl cariprazine.

Desmethyl cariprazine · Didesmethyl cariprazine · Open Desmethyl cariprazine in the interactive console ↗