Desmethylcariprazine
cariprazine metabolite DCAR
What it isFirst N-desmethyl metabolite of cariprazine, equipotent at D3 and D2.
Why it mattersExtends cariprazine’s effect well beyond the parent’s own half-life.
What it changesWith the didesmethyl metabolite, explains why cariprazine takes weeks to reach steady state and clear.
Used for
- schizophrenia/bipolar (metabolite of cariprazine)
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
Active metabolites
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Self-check
- How does desmethylcariprazine potency compare at D3/D2?
Equipotent. - How long can cariprazine and its metabolites take to reach steady state and clear?
Weeks.