Desmethyl cariprazine
cariprazine metabolite DCAR
What it isThe first N-desmethyl metabolite of cariprazine, equipotent at D3 and D2.
Why it mattersIt extends cariprazine’s effect well beyond the parent’s own half-life.
What it changesTogether with the didesmethyl metabolite it is why cariprazine takes weeks to reach steady state and weeks to clear.
FDA-approved for
- schizophrenia/bipolar (metabolite of cariprazine)
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
Clinical profile
Active metabolites
Mechanism of action: Desmethyl cariprazine ballicule
