Precursor to metabolite: Clozapine to Norclozapine
Clozapine is converted to Norclozapine by CYP1A2.
The pair
- Clozapine — Most effective antipsychotic; used in treatment-resistant cases despite agranulocytosis risk.
- Norclozapine — Active clozapine metabolite; M1 agonist implicated in some clozapine effects.
Anything that inhibits or induces CYP1A2 shifts the balance between Clozapine and Norclozapine.
Clozapine · Norclozapine · Open Clozapine in the interactive console ↗