Precursor to metabolite: Clopidogrel to Clopidogrel active metabolite
Clopidogrel is converted to Clopidogrel active metabolite by CYP2C19.
The pair
- Clopidogrel — P2Y12 antiplatelet prodrug; CYP2C19 variants blunt its effect.
- Clopidogrel active metabolite — Reactive thiol metabolite that irreversibly blocks platelet P2Y12 receptors; its formation depends partly on CYP2C19.
Anything that inhibits or induces CYP2C19 shifts the balance between Clopidogrel and Clopidogrel active metabolite.
Clopidogrel · Clopidogrel active metabolite · Open Clopidogrel in the interactive console ↗