Clopidogrel active metabolite

What it isThe thiol metabolite of clopidogrel, an irreversible P2Y12 antagonist.

Why it mattersIt is the species that blocks platelets — clopidogrel itself is entirely inactive.

What it changes⛑ CYP2C19 makes it, so poor metabolizers and omeprazole blunt the antiplatelet effect. Irreversible: platelet function returns only as new platelets form.