Precursor to metabolite: Clomipramine to Desmethyl clomipramine
Clomipramine is converted to Desmethyl clomipramine by CYP2C19.
The pair
- Clomipramine — The most serotonergic TCA; the TCA of choice for OCD.
- Desmethyl clomipramine — Clomipramine's metabolite, which shifts the parent's serotonergic profile toward noradrenergic reuptake block.
Anything that inhibits or induces CYP2C19 shifts the balance between Clomipramine and Desmethyl clomipramine.
Clomipramine · Desmethyl clomipramine · Open Clomipramine in the interactive console ↗