Precursor to metabolite: Clomipramine to Desmethylclomipramine
Clomipramine is converted to Desmethylclomipramine by CYP2C19.
The pair
- Clomipramine — Most serotonergic TCA; preferred TCA for OCD.
- Desmethylclomipramine — Clomipramine metabolite shifting the parent's serotonergic profile toward noradrenergic reuptake block.
Anything that inhibits or induces CYP2C19 shifts the balance between Clomipramine and Desmethylclomipramine.
Clomipramine · Desmethylclomipramine · Open Clomipramine in the interactive console ↗