Precursor to metabolite: Carbamazepine to Carbamazepine-10,11-epoxide
Carbamazepine is converted to Carbamazepine-10,11-epoxide by CYP3A4.
The pair
- Carbamazepine — Anticonvulsant/mood stabilizer and potent autoinducer; HLA-B*1502 rash risk.
- Carbamazepine-10,11-epoxide — Active epoxide metabolite of carbamazepine; cleared by epoxide hydrolase, which valproate inhibits.
Anything that inhibits or induces CYP3A4 shifts the balance between Carbamazepine and Carbamazepine-10,11-epoxide.
Carbamazepine · Carbamazepine-10,11-epoxide · Open Carbamazepine in the interactive console ↗