Precursor to metabolite: Aripiprazole monohydrate LAI to Dehydro aripiprazole
Aripiprazole monohydrate LAI is converted to Dehydro aripiprazole by CYP2D6 / CYP3A4.
The pair
- Aripiprazole monohydrate LAI — Long-acting aripiprazole for schizophrenia and bipolar maintenance; akathisia remains prominent.
- Dehydro aripiprazole — Aripiprazole's long-lived active metabolite, with the same D2 partial agonism and a large share of steady-state exposure.
Anything that inhibits or induces CYP2D6, CYP3A4 shifts the balance between Aripiprazole monohydrate LAI and Dehydro aripiprazole.
Aripiprazole monohydrate LAI · Dehydro aripiprazole · Open Aripiprazole monohydrate LAI in the interactive console ↗