Precursor to metabolite: Aripiprazole monohydrate LAI (ABILIFY MAINTENA) to Dehydroaripiprazole

Aripiprazole monohydrate LAI is converted to Dehydroaripiprazole by CYP2D6 / CYP3A4.

The pair

Aripiprazole monohydrate LAI — Long-acting aripiprazole for schizophrenia and bipolar maintenance; akathisia remains prominent.
Dehydroaripiprazole — Long-lived active aripiprazole metabolite; same D2 partial agonism, large share of steady-state exposure.

Anything that inhibits or induces CYP2D6, CYP3A4 shifts the balance between Aripiprazole monohydrate LAI and Dehydroaripiprazole.