Precursor to metabolite: Aripiprazole lauroxil LAI (ARISTADA INITIO) to Dehydroaripiprazole

Aripiprazole lauroxil LAI is converted to Dehydroaripiprazole by CYP2D6 / CYP3A4.

The pair

Aripiprazole lauroxil LAI — Rapid-start aripiprazole lauroxil injection used only to initiate Aristada treatment.
Dehydroaripiprazole — Long-lived active aripiprazole metabolite; same D2 partial agonism, large share of steady-state exposure.

Anything that inhibits or induces CYP2D6, CYP3A4 shifts the balance between Aripiprazole lauroxil LAI and Dehydroaripiprazole.