Precursor to metabolite: Aripiprazole lauroxil LAI to Dehydro aripiprazole
Aripiprazole lauroxil LAI is converted to Dehydro aripiprazole by CYP2D6 / CYP3A4.
The pair
- Aripiprazole lauroxil LAI — Long-acting aripiprazole prodrug injection for schizophrenia; requires a loading strategy.
- Dehydro aripiprazole — Aripiprazole's long-lived active metabolite, with the same D2 partial agonism and a large share of steady-state exposure.
Anything that inhibits or induces CYP2D6, CYP3A4 shifts the balance between Aripiprazole lauroxil LAI and Dehydro aripiprazole.
Aripiprazole lauroxil LAI · Dehydro aripiprazole · Open Aripiprazole lauroxil LAI in the interactive console ↗