Precursor to metabolite: Aripiprazole to Dehydro aripiprazole
Aripiprazole is converted to Dehydro aripiprazole by CYP2D6 / CYP3A4.
The pair
- Aripiprazole — D2 partial agonist; weight-favorable, activating, low prolactin; can cause akathisia.
- Dehydro aripiprazole — Aripiprazole's long-lived active metabolite, with the same D2 partial agonism and a large share of steady-state exposure.
Anything that inhibits or induces CYP2D6, CYP3A4 shifts the balance between Aripiprazole and Dehydro aripiprazole.
Aripiprazole · Dehydro aripiprazole · Open Aripiprazole in the interactive console ↗