Precursor to metabolite: Aripiprazole to Dehydroaripiprazole
Aripiprazole is converted to Dehydroaripiprazole by CYP2D6 / CYP3A4.
The pair
- Aripiprazole — D2 partial agonist; weight-favorable, activating, low prolactin; can cause akathisia.
- Dehydroaripiprazole — Long-lived active aripiprazole metabolite; same D2 partial agonism, large share of steady-state exposure.
Anything that inhibits or induces CYP2D6, CYP3A4 shifts the balance between Aripiprazole and Dehydroaripiprazole.
Aripiprazole · Dehydroaripiprazole · Open Aripiprazole in the interactive console ↗