V2 agonist
V2 vasopressin receptor agonist
- Renal aquaporin insertion → free-water retention
- In kidney → aquaporin-2 insertion (collecting duct)
- Treats central diabetes insipidus and nocturnal enuresis
- Excess antidiuresis → hyponatremia
- Endothelial V2 → ↑ von Willebrand factor and factor VIII release
- hemophilia A
- von Willebrand Disease Type
- urgent reversal of platelet dysfunction
Drugs with this mechanism (3)
- Desmopressin — Vasopressin V2 analog for diabetes insipidus, enuresis, and bleeding.
- Terlipressin — Vasopressin analog for hepatorenal syndrome; respiratory failure limits use.
- Vasopressin — Antidiuretic hormone; a vasopressor in shock and treatment for diabetes insipidus.
Self-check
- Which channel is inserted in the collecting duct after V2 stimulation?
Aquaporin-2. - What does endothelial V2 stimulation release?
Von Willebrand factor and factor VIII.
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