THR-β agonist
Thyroid hormone receptor β agonist
- THR-β predominates in liver and pituitary — hepatic lipid handling and TSH feedback
- Thyroid hormone activates both isoforms; resmetirom is β-selective and liver-directed, treating MASH without the cardiac α effects
- Pituitary β is the TSH suppression that monitors replacement
- THR-β predominates in liver and pituitary — hepatic lipid handling and TSH feedback
- Thyroid hormone activates both isoforms; resmetirom is β-selective and liver-directed, treating MASH without the cardiac α effects
- Pituitary β is the TSH suppression that monitors replacement
Drugs with this mechanism (4)
- Levothyroxine — Synthetic T4 replacement for hypothyroidism; absorption makes consistency essential.
- Liothyronine — Synthetic T3; faster, shorter-acting thyroid hormone than levothyroxine.
- Resmetirom — Thyroid-hormone-receptor-beta agonist; the first drug for NASH/MASH.
- Thyroid, desiccated — Porcine T4/T3 extract for hypothyroidism; its hormone ratio differs from human secretion.
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