THR-α agonist
Thyroid hormone receptor α agonist
- THR-α predominates in heart, bone and brain — heart rate, contractility and bone turnover run through it
- Thyroid hormone activates both isoforms; the atrial fibrillation and bone loss of over-replacement are α effects
- Isoform-selective drugs are designed to avoid it
- THR-α predominates in heart, bone and brain — heart rate, contractility and bone turnover run through it
- Thyroid hormone activates both isoforms; the atrial fibrillation and bone loss of over-replacement are α effects
- Isoform-selective drugs are designed to avoid it
Drugs with this mechanism (3)
- Levothyroxine — Synthetic T4 replacement for hypothyroidism; absorption makes consistency essential.
- Liothyronine — Synthetic T3; faster, shorter-acting thyroid hormone than levothyroxine.
- Thyroid, desiccated — Porcine T4/T3 extract for hypothyroidism; its hormone ratio differs from human secretion.
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