Direct thrombin inhibitor
- No fibrin formation or platelet activation
- Direct thrombin inhibition
- Anticoagulation, including in heparin-induced thrombocytopenia
- Bleeding is the direct consequence
Drugs with this mechanism (3)
- Argatroban — Hepatically cleared IV direct thrombin inhibitor for HIT; falsely raises INR.
- Bivalirudin — Short-acting IV direct thrombin inhibitor used during PCI and when heparin is unsuitable.
- Dabigatran — Oral direct thrombin inhibitor anticoagulant; idarucizumab reverses it.
Self-check
- Which clot protein fails to form with thrombin inhibition?
Fibrin. - Which listed anticoagulant directly inhibits thrombin?
Dabigatran.
All mechanisms · Open Direct thrombin inhibitor in the interactive console ↗