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Serotonin releaser

• Drives serotonin out of the terminal
• High serotonin toxicity risk, especially with MAO inhibitors

Drugs with this mechanism (10)

• Mixed amphetamine salts XR — Extended-release stimulant for ADHD; long coverage with Schedule II misuse risk.
• Amphetamine XR-ODT — Extended-release orally disintegrating amphetamine for ADHD; no pill swallowing needed.
• Amphetamine — Monoamine-releasing stimulant for ADHD and narcolepsy; effective but readily misused.
• Amphetamine XR suspension — Extended-release liquid amphetamine for ADHD; useful when pills are difficult.
• Amphetamine racemic (1:1) — Racemic amphetamine for ADHD; more peripheral sympathomimetic effect than dextro-rich products.
• Fenfluramine — Serotonin releaser once in "fen-phen"; now for Dravet seizures, valvulopathy risk.
• Methylenedioxy­ methamphetamine — Serotonin releaser (empathogen) under study for PTSD.
• Mephedrone — Synthetic cathinone ("meow meow") stimulant; a monoamine releaser.
• Methamphetamine — Potent, CNS-penetrant amphetamine; high addiction liability, rare medical use.
• Mixed amphetamine salts (triple-bead) — Triple-bead extended-release mixed amphetamine salts for all-day ADHD coverage.

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