NKCC2 inhibitor
Sodium-potassium-chloride cotransporter 2 inhibitor
- Thick ascending limb of the loop of Henle
- Potent natriuresis/diuresis
- Potassium and magnesium loss
- Ototoxicity
- ↑ urinary calcium
Drugs with this mechanism (4)
- Bumetanide — Potent loop diuretic; more predictable absorption than furosemide.
- Ethacrynic acid — Only non-sulfonamide loop diuretic; most ototoxic.
- Furosemide — The prototypical loop diuretic; workhorse for edema and heart failure.
- Torsemide — Loop diuretic with better oral bioavailability than furosemide.
Self-check
- Where does NKCC2 inhibition act?
The thick ascending limb of the loop of Henle. - How does NKCC2 inhibition affect urinary calcium?
Increases it.
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