NK1 antagonist
Neurokinin-1 receptor antagonist
- ↓ substance-P signaling in emetic pathways
- Prevents delayed chemotherapy-induced nausea/vomiting
Drugs with this mechanism (4)
- Aprepitant — NK1 antagonist antiemetic for delayed chemotherapy nausea.
- Elinzanetant — Dual NK1/NK3 (neurokinin) antagonist; hormone-free relief for menopausal hot flashes.
- Netupitant — Long-acting NK1 antagonist in a fixed pair with palonosetron.
- Rolapitant — Long-acting NK1 antiemetic for chemotherapy.
Self-check
- Which signal is reduced in emetic pathways by NK1 blockade?
Substance-P signaling. - Which phase of chemotherapy-induced nausea/vomiting does NK1 blockade prevent?
Delayed.
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