Elinzanetant

LYNKUET

Open Elinzanetant in the interactive console ↗

Pronunciation: e-lin-ZA-ne-tant (lin-kyoo-ET)

Elinzanetant ballicule: receptor binding, kinetics and half-life diagram — Mechanism of action: Elinzanetant ballicule

What it isDual NK1 and NK3 receptor antagonist; menopausal vasomotor symptoms.

Why this oneBlocking both neurokinin pathways targets hot flashes and associated sleep disruption without hormones.

What limits itCheck liver tests; transaminase elevation can end treatment, while somnolence and dizziness make driving unsafe.

Elinzanetant molecular structure (skeletal formula) — Molecular structure: Elinzanetant

FDA-approved for

menopausal vasomotor symptoms (2025)

Principal riskTransaminase rise

Classes and tags

Clinical profile

Therapeutic safety burden1 / 4

Overdose danger1 / 4

Weight-gain liability0 / 4

Sedation liability1 / 4

QT / Torsades0 / 4

Direct muscarinic antagonism0 / 4

Embryofetal risk4 / 4

Legacy pregnancy categoryNot assigned — PLLR-era drug

Defining liabilityGenerally tolerated at therapeutic doses; clinically important risks are agent-specific and increase with interactions or organ impairment.

FDA label

Read the full label on DailyMed ↗

NO BOXED WARNINGS

FDA dosing	Population	Start	Target	Max
Moderate to severe vasomotor symptoms due to menopause	Adults	120 mg QHS	120 mg QHS	120 mg QHS

Renal End-stage renal disease (with or without hemodialysis): not recommended

Hepatic Moderate to severe hepatic impairment: not recommended; do not start if ALT/AST ≥2×ULN or total bilirubin ≥2×ULN

Instructions

Take 120 mg (two 60 mg capsules) at bedtime, about the same time each day, with water; with or without food.
Swallow capsules whole; do not cut, crush, or chew.
Obtain baseline hepatic labs; do not start if transaminases or bilirubin ≥2×ULN; recheck at 3 months.
If a dose is missed, take the next dose as scheduled; do not double.

Available strengths

cap 60 mg

Contraindications

Pregnancy — may cause pregnancy loss or stillbirth

Cautions

CNS depressant effect and daytime impairment (somnolence)
Hepatic transaminase elevations
Risk of pregnancy loss or stillbirth
Risk of seizure

Adverse reactions

Headache
Fatigue
Dizziness
Somnolence

Pregnancy Contraindicated; may cause pregnancy loss or stillbirth.

Lactation No human data; elinzanetant present in animal milk.

Cost

Elinzanetant (LYNKUET)

What pharmacies pay · NADAC 9/30/26

Strength		#/mo	generic $/mo	brand $/mo	CostPlus
60 mg	cap	30 qd	—	$299.12	not offered

Generic entry2039 est.

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Self-check

Which two neurokinin receptors does elinzanetant block?
NK1 and NK3.
Which laboratory tests require checking?
Liver tests.