NCC inhibitor
Sodium-chloride cotransporter inhibitor
- Modest distal-tubule natriuresis with potassium and magnesium loss
- The thiazides
- Hyponatremia, hyperuricemia
- ↓ urinary calcium — useful in calcium stones and osteoporosis
- ↓ blood pressure
Drugs with this mechanism (5)
- Chlorothiazide — The original thiazide diuretic; the only one available in an intravenous form.
- Chlorthalidone — Long-acting thiazide-like diuretic; preferred for hypertension outcomes.
- Hydrochlorothiazide — The most-prescribed thiazide diuretic for hypertension.
- Indapamide — Thiazide-like diuretic antihypertensive.
- Metolazone — Thiazide-like diuretic that works even in renal impairment; adds to loop diuretics.
Self-check
- How does NCC inhibition affect urinary calcium?
Decreases it. - Which electrolytes are lost with NCC-mediated distal-tubule natriuresis?
Potassium and magnesium.
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