Muscle nAChR agonist

Muscle-type nicotinic acetylcholine receptor agonist

Skeletal muscle contraction
➔ depolarizing neuromuscular blockade → paralysis

Drugs with this mechanism (2)

Acetylcholine — Endogenous neurotransmitter at muscarinic and nicotinic receptors.
Succinylcholine — The only depolarizing neuromuscular blocker; fastest onset, malignant hyperthermia risk.

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