Ganglionic blocker
Ganglionic nicotinic (α3β4) receptor antagonist
- Blocks transmission in sympathetic AND parasympathetic ganglia — each organ loses whichever tone dominates it
- Orthostatic hypotension, ileus, urinary retention, cycloplegia — why hexamethonium is history and mecamylamine a niche drug
- Blocks transmission in sympathetic AND parasympathetic ganglia — each organ loses whichever tone dominates it
- Orthostatic hypotension, ileus, urinary retention, cycloplegia — why hexamethonium is history and mecamylamine a niche drug
Drugs with this mechanism (2)
- Hexamethonium — Ganglionic nicotinic blocker of historical interest.
- Mecamylamine — Ganglionic nicotinic blocker; studied as a smoking-cessation adjunct.
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