Non-absorbed mu-opioid antagonist
Mu-opioid receptor antagonist, not absorbed (naloxone in SUBOXONE)
- Naloxone in SUBOXONE: a potent μ antagonist absorbed only in small amounts sublingually — measurable levels, no clinically significant effect (label)
- Injected, it is fully active and precipitates withdrawal in anyone dependent on a full agonist — the misuse deterrent
- Drawn faded: usually clinically irrelevant; buprenorphine carries the pharmacology
- Naloxone in SUBOXONE: a potent μ antagonist absorbed only in small amounts sublingually — measurable levels, no clinically significant effect (label)
- Injected, it is fully active and precipitates withdrawal in anyone dependent on a full agonist — the misuse deterrent
- Drawn faded: usually clinically irrelevant; buprenorphine carries the pharmacology
Drugs with this mechanism (1)
- Sublingual naloxone — The naloxone component of SUBOXONE; absorbed only in small amounts sublingually, so it matters only if the product is misused by injection.
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