Sublingual naloxone

What it isMu-opioid antagonist paired with buprenorphine in SUBOXONE as a misuse deterrent.

Why this oneThe label: naloxone "is absorbed in small amounts by the sublingual route" and "had no clinically significant effect when administered by the sublingual route, although blood levels of the drug were measurable."

What limits itMisused parenterally it precipitates withdrawal in anyone dependent on a full agonist; buccal dosing exposes more naloxone than sublingual, so induction uses the sublingual site.