mTOR inhibitor
Mechanistic target of rapamycin inhibitor
- ↓ T-cell activation → immunosuppression
- ↓ cell growth/proliferation → anticancer
- Impaired repair → mouth ulcers, poor wound healing
- Metabolic effects: hyperlipidemia, hyperglycemia
Drugs with this mechanism (3)
- Everolimus — mTOR inhibitor immunosuppressant and anticancer agent.
- Sirolimus — mTOR inhibitor immunosuppressant (rapamycin).
- Temsirolimus — IV mTOR inhibitor for renal cell carcinoma; converts to sirolimus.
Self-check
- Which oral adverse effect can follow impaired repair during mTOR inhibition?
Mouth ulcers. - Which metabolic effects accompany mTOR inhibition?
Hyperlipidemia and hyperglycemia.
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