Mineralocorticoid agonist
Mineralocorticoid receptor agonist
- ↑ renal sodium/water retention and potassium excretion → ↑ volume and BP
- Exploited therapeutically in orthostatic hypotension and adrenal insufficiency
- Fludrocortisone
Drugs with this mechanism (4)
- Aldosterone — Endogenous mineralocorticoid driving sodium retention and potassium loss.
- Fludrocortisone — Potent mineralocorticoid for adrenal insufficiency and orthostatic hypotension.
- Hydrocortisone — Cortisol given as a drug; physiologic replacement and topical steroid.
- Hydrocortisone topical — Low-potency topical corticosteroid for mild dermatoses; suitable for face and skin folds.
Self-check
- How does mineralocorticoid agonism affect potassium excretion?
Increases it. - Which hypotension syndrome is treated with mineralocorticoid agonism?
Orthostatic hypotension.
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